the effects of losartan on memory performance and leptin resistance induced by obesity and high-fat diet in adult male rats

Authors

seyydeh gohar sharieh hosseini islamic azad university, kazerun branch, department of physiology, kazerun, iran

saeed khatamsaz islamic azad university, zarghan branch, iran

mehrdad shariati islamic azad university, kazerun branch, department of physiology, kazerun, iran

abstract

objective(s): leptin is a hormone secreted by adipose tissue and is involved not only in the regulation of feeding and energy expenditure, but also its role in memory enhancement has been demonstrated as well. the partial transfer of leptin across the blood-brain barrier in obese individuals causes leptin resistance and prevents leptin reaching brain. on the other hand, studies have shown that angiotensin antagonists such as losartan can improve memory and learning abilities. the aim of this study was to evaluate the effects of losartan on improving memory and leptin resistance induced by high fat diet in obese rats.   materials and methods:   40 wistar male rats were divided in 4 groups: control (c), losartan (los), high-fat diet (hfd) and high-fat diet and losartan (hfd and los). the spatial memory performances of the rats were assessed in the morris water maze after 2 months of treatment. then they were weighed and serum levels of leptin and triglyceride were measured.   results: in spite of receiving high-fat diet, no significant differences in body weight were observed in the (hfd & los) group. in the morris water maze trial, the (los) and (hfd & los) groups also showed a significant reduction (p <0.05) in latency and path length. in addition, a significant decrease (p <0.05) in serum levels of leptin and no significant difference in serum levels of triglyceride was observed in the (hfd & los) group.   conclusion: losartan can improve leptin resistance induced by obesity and high fat diet. at the same time, it modulates body weight and enhances learning and memory.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

The effects of losartan on memory performance and leptin resistance induced by obesity and high-fat diet in adult male rats

  Objective(s): Leptin is a hormone secreted by adipose tissue and is involved not only in the regulation of feeding and energy expenditure, but also its role in memory enhancement has been demonstrated as well. The partial transfer of leptin across the blood-brain barrier in obese individuals causes leptin resistance and prevents leptin reaching brain. On the other hand, studies have show...

full text

The effects of losartan on memory performance and leptin resistance induced by obesity and high-fat diet in adult male rats

OBJECTIVE(S) Leptin is a hormone secreted by adipose tissue and is involved not only in the regulation of feeding and energy expenditure, but also its role in memory enhancement has been demonstrated as well. The partial transfer of leptin across the blood-brain barrier in obese individuals causes leptin resistance and prevents leptin reaching brain. On the other hand, studies have shown that a...

full text

The effects of high fat diet-induced obesity and interval and continuous exercise training on visceral fat SIRT1 and insulin resistance in male rats

Introduction. The aim of this study was to investigate the effects of high fat diet-induced obesity and interval and continuous exercise training on visceral fat SIRT1 and insulin resistance in male rats.  Method. Forty male rats were divided into two groups: high-fat diet (HFD; n=32) and standard diet (C; n=8). After 10 weeks inducing obesity, eight rats from the HFD and C groups were sacrifi...

full text

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Neurotrophic Effects of Swimming and Crocin Consumption on the Rats with Obesity Induced by a High-fat Diet

Introduction: Obesity is known as a multifactorial physical disorder. On the other hand, regular sport exercises and crocin consumption have beneficial effects on obesity. In this regard, the present study aimed to investigate the effect of eight weeks of swimming training with crocin consumption on neurotrophic factors in the heart tissue of obese rats. Methods</strong...

full text

Protective effects of troxerutin on maternal high-fat diet-induced impairments of spatial memory and apelin in the male offspring

Objective(s): Maternal high-fat diet (HFD) is linked with metabolic and cognitive deficits in offspring. Neuroprotective effects of troxerutin, a natural bioflavonoid, have been reported recently. This study aimed to investigate the effects of troxerutin on spatial memory and serum and hippocampal apelin levels in the male offspring of HFD fed mothers.Materials and Methods: Three-week-old femal...

full text

My Resources

Save resource for easier access later


Journal title:
iranian journal of basic medical sciences

جلد ۱۷، شماره ۱، صفحات ۴۱-۴۸

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023